NALP10 Antibody
Product Details
- Cat. No.
- 254349
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1beta, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1beta processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP10.
- Isotype: Rabbit Ig
- Gene: NP_789791
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)