Nanog rat antibody (mAb) (Clone 2E6E1)
Product Details
- Cat. No.
- 61627
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
Nanog (Nanog homeobox) is a transcriptional regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Clone: 2E6E1
- Isotype: IgG2a
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Western Blotting (WB)