Product & ReviewsAntibodies

Nanog rat antibody (mAb) (Clone 2E6E1), sample

Product Details

Cat. No.
61628
Type
Primary Antibody
Clonality
Monoclonal
Host
Rat
Active Motif

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Description

Nanog (Nanog homeobox) is a transcriptional regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Clone: 2E6E1
  • Isotype: IgG2a

Handling

  • Quantity: 10 ug
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Immunocytochemistry (ICC)
  • Immunofluorescence (IF)
  • Western Blotting (WB)
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