NBS1 Antibody
Product Details
- Cat. No.
- 200163
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Nijmegen breakage syndrome protein 1 (NBS1) is a component of the MRE11/RAD50/NBN (MRN) complex, which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. NBS1 modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. Defects in NBS1 are the cause of Nijmegen breakage syndrome, cancer predisposition, and anemia.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat, Xenopus
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NBS1.
- Clone: ABT-1064
- Isotype: Rabbit Ig
- Gene: O60934, NP_002476
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)