Product & ReviewsAntibodies
NOGO Antibody
Product Details
- Cat. No.
- 251677
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Neurite outgrowth inhibitor (NOGO) plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 of NOGO reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of NOGO inhibit BACE1 activity and amyloid precursor protein processing.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NOGO.
- Isotype: Rabbit Ig
- Gene: Q9NQC3
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)