Product & ReviewsAntibodies

NOTCH3 Rabbit pAb

Product Details

Cat. No.
A13522
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
ABclonal Technology

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Description

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human, Mouse, Rat

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