OGG1 Rabbit mAb
Product Details
- Cat. No.
- A4997
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rabbit
Western blot - OGG1 Rabbit mAb (A4997)
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Description
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
Biological Information
- Clonality: Monoclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
