Product & ReviewsAntibodies

ORAI3 Antibody

Product Details

Cat. No.
253727
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human, Mouse
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human ORAI3.
  • Isotype: Rabbit Ig
  • Gene: Q9BRQ5

Handling

  • Quantity: 0.1 mg
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Immunocytochemistry (ICC)
  • Western Blotting (WB)
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