Osteocalcin antibody
Product Details
- Cat. No.
- orb259644
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
IHC-P image of human endometrial cancer tissue using Osteocalcin antibody (2.5 ug/ml)
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Description
Rabbit polyclonal antibody to osteocalcin is the most abundant non-collagenous protein in bone; comprising almost 2% of total protein in the human body. It is important in bone metabolism and is used as a clinical marker for bone turnover; but its precise function remains elusive. With no known enzyme activity; osteocalcin's function depends on its structure. That structure has now been determined by X-ray crystallography; to reveal a negatively charged protein surface that places five calcium ions in positions complementary to those in hydroxyapatite; an important mineral component of bone. Using this recognition mechanism; osteocalcin could potentially modulate the crystal morphology and growth of hydroxyapatite. And in this complex; the carboxy terminus of osteocalcin; which promotes the adhesion of osteoblasts and osteoclasts in bone replacement; is readily accessible.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Clone: NULL
- Conjugate: Unconjugated
- Isotype: IgG
- Gene: 632
Handling
- Quantity: 100 ?g; 200 ?g
- Storage: Store at 4°C for up to two weeks. For long term storage; aliquot and store at -20°C; avoid freeze/thaw cycles.
- Buffer: 10 mM PBS; 0.02% sodium azide
Applications
- ELISA (ELISA)
- Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
- Western Blotting (WB)
