Product & ReviewsAntibodies
Osteoprotegerin Antibody
Product Details
- Cat. No.
- 250800
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Osteoprotegerin (OPG) acts as a decoy receptor for RANKL by neutralizing its function in osteoclastogenesis. OPG inhibits osteoclast activation and promotes osteoclast apoptosis in vitro. OPG is up-regulated by increasing calcium concentration and estrogens. Defects in OPG are the cause of juvenile Paget disease, which is characterized by rapid bone remodeling leading to deformities, fractures ans osteopenia.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Horse (Equine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human osteoprotegerin.
- Isotype: Rabbit Ig
- Gene: O00300
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)