Product & ReviewsAntibodies
P14ARF Antibody
Product Details
- Cat. No.
- 251543
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
Cyclin-dependent kinase inhibitor 2A (P14ARF) is capable of inducing cell cycle arrest in G1 and G2 phases. P14ARF acts as a tumor suppressor. P14ARF binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. P14ARF also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human P14ARF.
- Isotype: Rabbit Ig
- Gene: Q8N726
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)