Product & ReviewsAntibodies
P16 (1E1) Antibody
Product Details
- Cat. No.
- 252703
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CDK4I or p16-INK4 (Cyclin-dependent kinase 4 inhibitor A) is a negative regulator of the proliferation of normal cells. It is interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, melanoma-astrocytoma syndrome and Li-Fraumeni syndrome.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse, Rat
- Antigen: Purified recombinant fragment of P16 expressed in E. coli.
- Clone: 1E12E10
- Isotype: Mouse IgG1
- Gene: P42771
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)