Product & ReviewsAntibodies
p16-INK4 Antibody
Product Details
- Cat. No.
- 250804
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The cyclin-dependent kinase 4 inhibitor A (CDK4I or p16-INK4) acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, melanoma-astrocytoma syndrome and Li-Fraumeni syndrome.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Chicken, Dog (Canine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human p16-INK4.
- Isotype: Rabbit Ig
- Gene: P42771
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)