PADI4 Antibody
Product Details
- Cat. No.
- 250811
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Protein-arginine deiminase type-4 (PADI4) catalyzes the citrullination/deimination of arginine residues of proteins. PADI4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. PADI4 is expressed in eosinophils and neutrophils but is not expressed in peripheral monocytes or lymphocytes. PADI4 is a rheumatoid arthritis susceptibility locus due to its important role in increasing citrullination of proteins in rheumatoid arthritis synovial tissues leading to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PADI4.
- Isotype: Rabbit Ig
- Gene: Q9UM07
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)