PAK-1/2/3 (Thr402) Antibody
Product Details
- Cat. No.
- 252569
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Serine/threonine-protein kinase PAK-1 (PAK-1) is a protein kinase that acts on a variety of targets. PAK-1 is the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK-1 is activated by CDC42 and RAC1, and is involved in dissolution of stress fibers and reorganization of focal complexes. PAK-1 is involved in regulation of microtubule biogenesis through phosphorylation of TBCB. PAK-1 activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Autophosphorylation of Thr402 has been found to be essential for activation of PAK.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Thr402 of rat PAK-1, 2, 3. Thr402 in PAK-2 corresponds to Thr423 in human PAK-1.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P35465
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)