PALB2 Antibody
Product Details
- Cat. No.
- 251230
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Partner and localizer of BRCA2 (PALB2) plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. PALB2 serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. PALB2 strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN). FANCN is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PALB2.
- Isotype: Rabbit Ig
- Gene: Q86YC2
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)