Pan-Cadherin Antibody
Product Details
- Cat. No.
- 251786
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Chicken, Human, Mouse, Rabbit (Lapine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin.
- Clone: PC-79
- Isotype: Mouse IgG1
- Gene: P10288
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)