Paxillin Antibody
Product Details
- Cat. No.
- 251787
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Paxillin is a signal transduction adaptor protein. The C-terminal region of paxillin contains four LIM domains which target paxillin to focal adhesions, presumably through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein–protein interaction sites. The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and FAK, structural proteins, such as vinculin and actopaxin, and regulators of actin organization, such as COOL/PIX and PKL/GIT. Paxillin is tyrosine-phosphorylated by FAK and Src upon integrin engagement or growth factor stimulation, creating binding sites for the adapter protein Crk.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Chicken, Human, Mouse, Rat
- Antigen: Recombinant C-terminal chicken paxillin (aa 305-559)
- Clone: PAX-14
- Isotype: Mouse IgG1
- Gene: P49024
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunocytochemistry (ICC)
- Western Blotting (WB)