PDL-1 Antibody

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform. PDL-1 antibody has no cross-reactivity to PDL-2.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PDL-1.
• Isotype: Rabbit Ig
• Gene: NP_054862

• Quantity: 0.1 mg
• Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
• Specificity: 5

• ELISA (ELISA)
• Immunofluorescence (IF)
• Immunohistochemistry (IHC)
• Western Blotting (WB)