Product & ReviewsAntibodies

PGC1-b rabbit antibody (pAb)

Product Details

Cat. No.
39859
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Active Motif

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Description

PGC1-b (Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PPARGC1B, PERC) is a co-activator of transcription by nuclear receptors and transcription factors. PGC1-b participates in modulating the transcriptional activity of PPAR alpha and gamma, ER alpha, NRF1 and GR. It is likely involved in fat oxidation, non-oxidative glucose metabolism and in the regulation of energy expenditure. Expression of PGC1-b is repressed by saturated fatty acids in skeletal muscle cells and induced by insulin. PGC1-b is down-regulated in type 2 diabetes as well as in pre-diabetics. Allelic variation of PGC1-b may contribute to the pathogenesis of obesity, with the widespread Ala-203 variation being a significant risk factor for the development of this diabetes.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human
  • Isotype: IgG

Handling

  • Quantity: 100 ul
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Western Blotting (WB)
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