PGC1-b rabbit antibody (pAb)
Product Details
- Cat. No.
- 39859
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
PGC1-b (Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PPARGC1B, PERC) is a co-activator of transcription by nuclear receptors and transcription factors. PGC1-b participates in modulating the transcriptional activity of PPAR alpha and gamma, ER alpha, NRF1 and GR. It is likely involved in fat oxidation, non-oxidative glucose metabolism and in the regulation of energy expenditure. Expression of PGC1-b is repressed by saturated fatty acids in skeletal muscle cells and induced by insulin. PGC1-b is down-regulated in type 2 diabetes as well as in pre-diabetics. Allelic variation of PGC1-b may contribute to the pathogenesis of obesity, with the widespread Ala-203 variation being a significant risk factor for the development of this diabetes.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Isotype: IgG
Handling
- Quantity: 100 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Western Blotting (WB)