Phospho-CREB-1 (Ser133) Antibody
Product Details
- Cat. No.
- 250813
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA, a sequence present in many viral and cellular promoters. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1, ATF-2, ATF-3 and ATF-4. These transcription factors share highly-related COOH terminal leucine zipper dimerization and basic DNA binding but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in certain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recently been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265-kDa nuclear protein designated CBP (CREB-binding protein), which represents a CREB co-activator. Phosphorylation of Ser-133 is key for CREB transcriptional activity.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser-133 region of human CREB1.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P16220
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)