Product & ReviewsAntibodies
Phospho-MDM2-S260 Rabbit pAb
Product Details
- Cat. No.
- AP0074
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - phospho-MDM2-S260 antibody (AP0074)
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Description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
