Product & ReviewsAntibodies

Phospho-ZAP70-Y493 Rabbit pAb

Product Details

Cat. No.
AP0468
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
ABclonal Technology

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human, Mouse, Rat

Handling

    Applications

      Specificity rating
      Sensitivity rating
      Quality rating
      Write your own review

      Product Overview

      Links