Product & ReviewsAntibodies

PHOX2B Rabbit mAb

Product Details

Cat. No.
A6816
Type
Primary Antibody
Clonality
Monoclonal
Host
Rabbit
ABclonal Technology

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Description

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]

Biological Information

  • Clonality: Monoclonal
  • Host: Rabbit
  • Reactivity: Human, Mouse

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