Product & ReviewsAntibodies
Pirh2 (1H10) Antibody
Product Details
- Cat. No.
- 252965
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Pirh 2 (P53 induced RING-H2 protein) mediates E3-dependent ubiquitination and proteasomal degradation of proteins. Pirh2 has ubiquitin-protein ligase activity and binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered together with MDM2, to act as a negative regulator of p53 function.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Rat
- Antigen: Purified recombinant fragment of human Pirh2 expressed in E. coli.
- Clone: 1H10
- Isotype: Mouse IgG1
- Gene: Q96PM5
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Flow Cytometry (FC)
- Immunofluorescence (IF)
- Western Blotting (WB)