Product & ReviewsAntibodies

PIWIL2 Antibody

Product Details

Cat. No.
252137
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

Piwi-like protein 2 (PIWIL2) plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. PIWIL2 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governing the methylation and subsequent repression of transposons. PIWIL2 binds pi RNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism. PIWIL2 is also involved in the formation of chromatoid bodies and is required for some piRNAs stability.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human, Mouse, Rat
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human PIWIL2.
  • Isotype: Rabbit Ig
  • Gene: Q8TC59

Handling

  • Quantity: 0.1 mg
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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