PLGF Antibody
Product Details
- Cat. No.
- 250825
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Placenta growth factor (PLGF or PIGF) is a dimeric glycoprotein showing the highest degree of sequence similarity to the vascular endothial growth factor. Alternative splicing of the PLGF primary transcript gives rise to three forms named PIGF-1, 2 and 3, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. PLGF is active in angiogenesis and endothelial cell growth by stimulating their proliferation and migration. PLGF binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner. Whereas the three forms are present in most placental tissues, PIGF-2 is specific to early (8 week) placenta and only PIGF-1 is found in the colon and mammary carcinomas.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PLGF.
- Isotype: Rabbit Ig
- Gene: P49763
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)