Product & ReviewsAntibodies

PLGF (Mouse) Antibody

Product Details

Cat. No.
250826
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

Placenta growth factor (PLGF or PIGF) is a dimeric glycoprotein showing the highest degree of sequence similarity to the vascular endothial growth factor. Alternative splicing of the PLGF primary transcript gives rise to three forms named PIGF-1, 2 and 3, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. PLGF is active in angiogenesis and endothelial cell growth by stimulating their proliferation and migration. PLGF binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner. Whereas the three forms are present in most placental tissues, PIGF-2 is specific to early (8 week) placenta and only PIGF-1 is found in the colon and mammary carcinomas.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Mouse, Rat
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse PLGF.
  • Isotype: Rabbit Ig
  • Gene: P49764

Handling

  • Quantity: 0.1 mg
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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