PML mouse antibody (mAb) (Clone 36.1-104)
Product Details
- Cat. No.
- 39773
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
PML (Promyelocytic Leukemia) protein is a transcription factor originally identified due to a chromosomal aberration fusing it to the Retinoic Acid Receptor alpha (RAR-A) in cases of Acute Promyelocytic Leukemia (APL). Besides transcriptional regulation, PML is involved in many processes, including the response to DNA damage, cell cycle regulation, viral infection response and apoptosis. These functions of PML involve the localization of PML to unique sub-nuclear structures called PML Nuclear Bodies (PML NBs). Over fifty proteins are know to be localized to PML NBs, either transiently or constitutively. These Nuclear Bodies are disrupted in PML knockout mice. PML is subject to a number of post-translational modifications, including phosphorylation, ubiquitylation and sumoylation.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Mouse
- Clone: 36.1-104
- Isotype: IgG
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunofluorescence (IF)
- Immunoprecipitation (IP)
- Western Blotting (WB)