PSTAIR Antibody
Product Details
- Cat. No.
- 251794
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The cell cycle is controlled in part by cyclin dependent kinases (CDKs) which are themselves controlled by modifications such as phosphorylation of CDKs and formation of complex(es) with other proteins, including the cyclins. CDKs are key regulators of cell cycle progression. CDKs are closely related in size (35-40 kD) and sequence (>40% identity) and associate with and are activated by a cyclin which acts as a regulatory subunit. In every eukaryote examined, CDKs contain an evolutionary conserved 16 amino acid sequence called PSTAIR (EGVPSTAIREISLLKE) which distinguishes them from other protein kinases. The PSTAIR motif is involved in the complex formation with cyclins. The availability of antibodies reacting specifically with the PSTAIR sequence enables the subcellular detection and localization of the various CDKs and examination of substrate interactions, in a variety of organisms.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Chicken, Hamster, Human, Mouse, Rat, Xenopus, Zebrafish
- Antigen: BSA-conjugated synthetic peptide containing the evolutionarily conserved PSTAIR sequence.
- Clone: IL-16
- Isotype: Mouse IgG1
- Gene: Q3U6X7
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)