PTGDR2 Antibody
Product Details
- Cat. No.
- 200215
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The Prostaglandin D2 receptor 2 (PTGDR2, CRTH2, GPR44) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. PTGDR2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of PTGDR2 are known to exist.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse
- Antigen: Recombinant mouse PTGDR2
- Isotype: Rabbit Ig
- Gene: Q9Z2J6
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)