Product & ReviewsAntibodies

PUMA (10C5G1) Antibody

Product Details

Cat. No.
253256
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human, Rat
  • Antigen: Amino acids 76 – 170 of human PUMA-alpha.
  • Clone: 10C5G1
  • Isotype: mouse IgG1
  • Gene: Q9BXH1

Handling

  • Quantity: 0.1 mg
  • Storage: Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Western Blotting (WB)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links