PUMA (2A8F6) Antibody
Product Details
- Cat. No.
- 253254
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Rat
- Antigen: Amino acids 76 – 170 of human PUMA-alpha.
- Clone: 2A8F6
- Isotype: mouse IgG1
- Gene: Q9BXH1
Handling
- Quantity: 0.1 mg
- Storage: Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)