Product & ReviewsAntibodies

PUMA Antibody

Product Details

Cat. No.
253425
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human, Mouse
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human PUMA.
  • Isotype: Rabbit Ig
  • Gene: NP_055232

Handling

  • Quantity: 0.1 mg
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Immunocytochemistry (ICC)
  • Western Blotting (WB)
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