PYK2 (5E2D) Antibody
Product Details
- Cat. No.
- 252776
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
PYK2 (PTK2B protein tyrosine kinase 2 beta) is a cytoplasmic protein tyrosine kinase. It is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PYK2 may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK and the SH2 domain of GRB2. This protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of PYK2(aa815-997) expressed in E. coli. <br>"
- Clone: 5E2D5
- Isotype: Mouse IgG2a
- Gene: Q14289
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)