RABBIT ANTI HUMAN CASPASE-2

recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human, Mouse
• Isotype: Polyclonal IgG

• Quantity: 50 µg
• Storage: +4ºC, -20ºC if preferred
• Buffer: Phosphate buffered saline, 0.02% Sodium Azide

• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Western Blotting (WB)