RABBIT ANTI HUMAN CASPASE-2
Product Details
- Cat. No.
- AHP1423
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Staining of formalin fixed, paraffin embedded human placenta with Rabbit anti Human caspase-2
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Description
recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse
- Isotype: Polyclonal IgG
Handling
- Quantity: 50 µg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.02% Sodium Azide
Applications
- Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
- Western Blotting (WB)
