RABBIT ANTI HUMAN INSULIN-LIKE GROWTH FACTOR I

Rabbit anti Human insulin-likegGrowth factor I antibody recognizes human IGF-I (Insulin-like Growth Factor I), a 70 amino acid secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver. IGF-I exhibits both autocrine and paracrine properties and has a widespread effect on cells including those of the bone, cartilage, muscle, nerves, skin, liver and lungs, playing a key role in cell proliferation and growth, inhibition of apoptosis and linked with tumour cell growth.IGF-I signals through binding to the type 1 insulin-like growth factor receptor (IGF-1R) and also to the insulin receptor (IR), resulting in the activation of the AKT signalling pathway. Production of IGF-I is stimulated by growth hormone (GH) and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Isotype: Polyclonal IgG

• Quantity: 0.1 mg
• Storage: -20ºC only
• Buffer: Phosphate buffered saline

• ELISA (ELISA)
• Functional Studies (Func)
• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Western Blotting (WB)