RABBIT ANTI HUMAN MUSCARINIC RECEPTOR M3
Product Details
- Cat. No.
- AHP1355
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Staining of formalin fixed, paraffin embedded human brain cortex
Receive your quote directly from the manufacturer.
Description
Rabbit anti Human muscarinic receptor M3 antibody detects the muscarinic receptor M3, a G protein-coupled receptor for acetylcholine which is expressed in smooth muscle and glandular tissues. The M3 subtype is coupled to other G proteins known as Go or Gq which activate phospholipase C leading to an increase in intracellular Ca2+. The M3 muscarinic receptor controls smooth muscle contraction in blood vessels and lungs as well as in the gastrointestinal tract. It is also located in many glands, and its activation helps to stimulate secretion.Mutations in the CHRM gene can lead to the development of Prune Belly Syndrome (PBS), a condition characterized by weak abdominal musculature, lax overlying skin, cryptorchism and urinary tract abnormalities (Weber et al. 2011).
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse
- Isotype: Polyclonal IgG
Handling
- Quantity: 50 µg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
