RABBIT ANTI HUMAN PRESENILIN-1 (LOOP)

Rabbit anti Human presenilin antibody recognizes presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue.PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes. Mutations of presenilin-1 are associated with early onset Alzheimer's disease.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human, Monkey
• Isotype: Polyclonal IgG

• Quantity: 0.1 ml
• Storage: +4ºC, -20ºC if preferred
• Buffer: 0.02% Sodium Azide

• Immunohistochemistry (Frozen Sections) (IHC (Fr))
• Immunoprecipitation (IP)
• Western Blotting (WB)