RABBIT ANTI NFkB p105

Rabbit anti NFkB p105 antibody recognizes Nuclear factor NF-kappa-B p105 subunit also known as DNA-binding factor KBF1 and Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. NF-kappa-B p105 is a large precursor protein that is cleaved at its C-terminus, containing a number of ankyrin repeats, by the ubiquitin/proteasome pathway into the NF-kappa-B p50 subunit. The p50 subunit is also known as NF-κB1 and interacts with members of the Rel protein family to form transcription factors. In the absence of stimulation an I-kappa-B inhibitory protein mediated sequestration mechanism ensures that the transcription factors remain in the cytoplasm. Upon stimulation, I-kappa-B proteins become phosphorylated, which results in their ubiquitylation and subsequent degradation by the 26S proteasome.The NF-kappa-B pathway plays a critical in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Isotype: Polyclonal IgG

• Quantity: 50 µg
• Storage: -20ºC only
• Buffer: Phosphate buffered saline, 30% Glycerol, 0.5% BSA, 0.01% Thiomersal

• Western Blotting (WB)