Product & ReviewsAntibodies
Raf-1 (Ser642) Antibody
Product Details
- Cat. No.
- 252579
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK. Previous studies have shown that phosphorylation is required for Raf-1 activation. Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf with two sites participating: Ser301 and Ser642.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Dog (Canine), Human, Monkey, Mouse, Rat
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser642 of rat raf-1.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P11345
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)