RAG2 (4D5) Antibody

RAG2 (V(D)J recombination-activating protein 2) is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Antigen: Purified recombinant fragment of human RAG2(350-527aa) expressed in E. coli.
• Clone: 4D5
• Isotype: Mouse IgG1
• Gene: P55895

• Quantity: 0.1 ml
• Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.

• Western Blotting (WB)