RAG2 Rabbit pAb
Product Details
- Cat. No.
- A12488
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - RAG2 antibody (A12488)
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Description
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse
