RASGRP1 Rabbit pAb
Product Details
- Cat. No.
- A10495
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - RASGRP1 antibody (A10495)
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Description
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
