RAT ANTI HUMAN HER2/neu
Product Details
- Cat. No.
- MCA1788
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
Rat anti Human HER2/neu antibody, clone ICR55 recognizes epitope E of human HER2/neu, otherwise known as CD340 and c-ErbB-2, a proto-oncogene expressed at the cell surface of a range of tumor cells, often associated with poor prognosis, and an increased risk of metastasis.HER2/neu is used in conjunction with antibodies recognizing both Estrogen and Progesterone receptors, for the classification of breast cancer tumors, and to determine patient prognosis and course of treatment. Excessive HER2/neu is present in around 20% to 25% of invasive breast cancers, referred to as HER2-positive cancer, and can help determine whether drugs such as trastuzumab (Herceptin) or lapatinib (Tykerb), might be beneficial.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Human
- Isotype: IgG2a
Handling
- Quantity: 0.2 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)
- Immunohistochemistry (Frozen Sections) (IHC (Fr))
- Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
- Immunoprecipitation (IP)
- Western Blotting (WB)