Product & ReviewsAntibodies
RAT ANTI MOUSE CD253
Product Details
- Cat. No.
- MCA4710GA
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
Rat anti Mouse CD253 antibody, clone N2B2 recognizes mouse CD253, also known as TNF-related apoptosis-inducing ligand or TRAIL, a member of the tumour necrosis factor ligand superfamily. When bound to the death receptors DR4 and DR5 caspase-8-dependent apoptosis is induced. However, CD253 might also be bound by the decoy receptor DcR1 which cannot induce apoptosis, and DcR2 which activates NF-kappa-B. Rat anti Mouse CD253 antibody, clone N2B2 has been reported to block NK cell cytotoxicity in vitro (Kayagaki et al. 1999).
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Isotype: IgG2a
Handling
- Quantity: 0.1 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.09% Sodium Azide
Applications
- Flow Cytometry (FC)