RBPJ rat antibody (mAb) (Clone 1F1)
Product Details
- Cat. No.
- 61505
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Human
- Clone: 1F1
- Isotype: IgG2b
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Chromatin Immunoprecipitation (ChIP)
- Gel Super Shift Assay (GSS)
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)