Rift Valley Fever Virus Antibody

Rift Valley Fever (RFV) virus is an arthropod-borne virus endemic to Africa that infects humans and animals that is transmitted predominantly by mosquitoes. During human infections, symptoms can range from benign fever to severe encephalitis and fatal hepatitis with hemorrhagic fever. The Bunyaviridae family of viruses to which the RVF virus belongs are spherical enveloped viruses with a tripartite RNA genome of negative or ambisense polarity. The three segments are referred to as the L, M, and S segments. The L and M segments are negative polarity and code fore the L-dependent RNA polymerase and glycoprotein precursor respectively. The S segment is of ambisense polarity and encodes the nucleoprotein and non-structural proteins. This RVF virus antibody was derived from a peptide sequence near the carboxy terminus of the polyprotein precursor translated from the M segment. It will therefore detect both the precursor and the Glycoprotein G2. Glycoprotein G1 and G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion.

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Virus
• Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of the RVF virus glycoprotein.
• Isotype: Rabbit Ig
• Gene: P03518

• Quantity: 0.1 mg
• Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

• ELISA (ELISA)