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Nuclear receptor ROR-gamma (RORC) is a nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. RORC is a key regulator of cellular differentiation, immunity, peripheral circadian rhytm as well as lipid, steroid, xenobiotics and glucose metabolism. Two isoforms are known for RORC: isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscles. Isoform 2 is primarily expressed in immature thymocytes.