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RUNX1 Antibody (A-2) is a high quality monoclonal RUNX1 antibody (also designated AML1 antibody or CBFA2 antibody) suitable for the detection of the RUNX1 protein of mouse, rat and human origin. RUNX1 Antibody (A-2) is available as both the non-conjugated anti-RUNX1 antibody form, as well as multiple conjugated forms of anti-RUNX1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is involved in hematopoiesis and is frequently targeted in human leukemia by chromosomal translocations that fuse the DNA-binding domain of RUNX1 to other transcription factors and corepressor molecules. In addition to its role in leukemogenesis, RUNX1 is also involved in sensory neuron diversification. Specifically, RUNX1 promotes axonal growth, is selectively expressed in neural crest-derived TrkA+ sensory neurons and mediates TrkA transactivation in migratory neural crest cells. Alternative splicing gives rise to several isoforms of RUNX1.
Good antibody.
Western blot
This antibody worked very well in our immunoblotting experiments. We got bright and reproducible signals. It was easy to use and storage at +4 degrees. The procedure of WB test is helpful either by following Santa CRUZ or LI-COR protocols. I am happy to rate this antibody as 5 star because of its high sensitivity, quality and their excellent tech service.
Review Date: 16 Oct 2020 | Santa Cruz Biotechnology Inc.
